8-Chlorotheophylline CAS 85-18-7, for Pharmaceutical Intermediates and Nitrogen-Containing Heterocyclic Compound Synthesis Applications

1. Product Overview

8-Chlorotheophylline is an important theophylline-based nitrogen-containing heterocyclic compound belonging to the xanthine derivative class. Due to its molecular structure containing a chlorine substituent and a purine dione skeleton, it serves as a significant intermediate in pharmaceutical synthesis for the preparation of related active compounds and functional fine chemicals.

The product exhibits high thermal stability and a well-defined structural profile, offering application value in pharmaceutical research and development, pharmaceutical intermediates, and fine chemical sectors.

2. Product Specifications

Product Name: 8-Chlorotheophylline

English Name: 8-Chlorotheophylline

CAS No.: 85-18-7

Test Date: June 5, 2024

Product Category: Pharmaceutical Intermediate / Nitrogen-Containing Heterocyclic Compound

3. Product Quality Specifications

Assay (Content): 98.6%

Specification Requirement: ≥98%

Melting Point: 290°C

Specification Range: 288–292°C

Moisture Content: 0.25%

Specification Requirement: ≤0.5%

Appearance: White Powder

4. Product Structural Characteristics

① Xanthine Core Structure

8-Chlorotheophylline possesses the theophylline-class core structure, belonging to an important class of nitrogen-containing heterocyclic compounds.

② Chlorine Substituent Structure

The introduction of a chlorine atom enables further functional group transformation and structural modification possibilities.

③ Highly Stable Crystalline Structure

The relatively high melting point reflects its favorable thermal stability and solid-state stability.

5. Main Application Areas

① Pharmaceutical Intermediates

Used in the synthesis of xanthine derivatives with specific biological activities.

② Drug Research and Development

Serves as an important raw material for structural optimization and molecular modification.

③ Fine Chemicals

Used in the development of nitrogen-containing heterocyclic functional compounds.

④ Research Reagents

Used in medicinal chemistry and organic synthesis research.

6. Product Characteristics and Advantages

① Stable Assay Content

The tested content of 98.6% meets the quality requirement of ≥98%.

② Stable Melting Point

Melting point of 290°C falls within the specification range.

③ Good Moisture Control

Moisture content of 0.25% meets the requirement of ≤0.5%.

④ White Powder Appearance

Suitable for use by pharmaceutical and fine chemical customers.

7. Russian Market Procurement Considerations

International customers typically focus on the following:

-Product Purity (Assay);

-Moisture Content;

-Melting Point Range;

-Appearance and Color;

-Impurity Control;

-Technical Documentation including COA, TDS, SDS;

-Stable Supply Capability.

8. Product Supply Advantages

Changzhou Jiayuan Chemical Co., Ltd. can provide supply services for pharmaceutical intermediates and fluorinated and nitrogen-containing fine chemicals.

Support includes:

-Batch Supply;

-Quality Test Reports;

-Technical Documentation Support;

-International Customer Procurement Requirements.

9. Distinctions from Related Products

① 8-Chlorotheophylline vs. Theophylline

8-Chlorotheophylline is a chlorine-substituted derivative based on the theophylline structure, offering richer reactivity.

② 8-Chlorotheophylline vs. Caffeine

Both belong to the xanthine compound class, but differ in substituents and application directions.

③ 8-Chlorotheophylline vs. Conventional Nitrogen-Containing Heterocyclic Intermediates

Its advantage lies in its clear medicinal chemistry application value.

10. Frequently Asked Questions (FAQ)

Q: What are the main applications of 8-Chlorotheophylline?

A: It is mainly used in pharmaceutical intermediates, drug research and development, and fine chemical sectors.

Q: What is the quality of this product?

A: According to the COA test from Changzhou Jiayuan Chemical Co., Ltd., the assay content is 98.6%, melting point is 290°C, moisture content is 0.25%, and the test conclusion is Qualified.

Q: What documentation is typically required for procurement?

A: COA, TDS, SDS, and batch test reports are typically required.