Trifluoromethanesulfonic Anhydride CAS 358-23-6, for High-End Organic Synthesis, Pharmaceutical Intermediates, and Fluorinated Fine Chemical Applications

1. Product Overview

Trifluoromethanesulfonic Anhydride (abbreviated as Tf₂O) is an important highly reactive fluorinated sulfonylating reagent, belonging to the category of high-end fluorinated fine chemicals.

This product consists of two trifluoromethanesulfonyl (CF₃SO₂⁻) groups, exhibiting strong electrophilic activity and excellent electronic effects. It is a commonly used powerful activating reagent in organic synthesis, widely applied in pharmaceuticals, pesticides, materials chemistry, and high-end fine chemical applications.

2. Product Specifications

Product Name: Trifluoromethanesulfonic Anhydride

English Name: Trifluoromethanesulfonic Anhydride

Abbreviation: Tf₂O

CAS No.: 358-23-6

Product Category: Fluorinated Sulfonylating Reagent / Fine Chemical Intermediate

Structural Type: Bis(trifluoromethanesulfonyl) Anhydride

Application Areas: Organic Synthesis, Pharmaceutical Intermediates, Electronic Chemicals

3. Product Structural Characteristics

① Bis(trifluoromethanesulfonyl) Structure

The two CF₃SO₂ groups confer strong electron-withdrawing capability and high reactivity, serving as the core structural feature of this activating reagent.

② Highly Active Sulfonylating Capability

Can be used for hydroxyl activation, triflate formation, and various organic functional group transformation reactions.

③ Highly Stable Fluorinated Structure

The CF₃ groups enhance molecular chemical stability while maintaining good reaction selectivity.

4. Main Application Areas

① Pharmaceutical Intermediate Synthesis

Used for hydroxyl activation, functional group transformations, and complex structure construction in drug molecule synthesis.

② Organic Synthesis

Serves as an important activating reagent for the preparation of triflates and other fluorinated derivatives.

③ Pesticide Intermediates

Used in the synthesis and development of fluorinated agrochemical products and functional molecules.

④ Electronic Chemicals and Materials Research & Development

Used in the study of high-purity functional chemicals and specialty materials.

5. Product Characteristics and Advantages

① High Reactivity

An important powerful activating reagent in the field of organic synthesis.

② High Value of Fluorinated Structure

The CF₃SO₂ structure imparts special electronic properties and application value.

③ Broad Application Scope

Covers pharmaceutical, agrochemical, electronic chemical, and fine chemical industry chains.

6. Distinctions from Related Products

① Trifluoromethanesulfonic Anhydride vs. Trifluoromethanesulfonic Acid

Trifluoromethanesulfonic acid is a strong acid product primarily used for catalysis and salt preparation; trifluoromethanesulfonic anhydride is mainly used as a highly active sulfonylating reagent.

② Trifluoromethanesulfonic Anhydride vs. N-Methyltrifluoromethanesulfonamide

The former is used for activation and introduction of trifluoromethanesulfonyl groups; the latter is a sulfonamide functional compound.

③ Trifluoromethanesulfonic Anhydride vs. Conventional Acid Anhydrides

The CF₃SO₂ structure provides stronger electronic effects and higher application value.

7. Russian Market Procurement Considerations

Customers typically focus on the following:

-Product Purity;

-Moisture Content;

-Acidic Impurities;

-Appearance and Color;

-Packaging Sealing and Corrosion Resistance;

-Technical Documentation including COA, TDS, SDS;

-Stable Supply Capability.

8. Product Supply Advantages

-Fluorinated Fine Chemical Supply Capability;

-Supports International Customer Procurement Requirements;

-Provides Complete Quality Documentation and Technical Data;

-Serves Pharmaceutical, Agrochemical, and Electronic Chemical Customers.

9. Frequently Asked Questions (FAQ)

Q: What are the main applications of Trifluoromethanesulfonic Anhydride?

A: It is mainly used as an organic synthesis activating reagent, in pharmaceutical intermediates, pesticide intermediates, and fluorinated fine chemical applications.

Q: Why does Trifluoromethanesulfonic Anhydride have high value?

A: Its CF₃SO₂ structure confers strong reactivity and special electronic properties, making it an important reagent in high-end synthesis applications.

Q: What documentation is typically required for procurement of this product?

A: COA, TDS, SDS, packaging information, and shipping documentation are typically required.